The translocation of calreticulin is associated with increased phagocytosis of tumor cells (Fig. 2d, Supplementary Fig. 4) and transcription of ER stress response-specific targets damage inducible protein 3 (DDIT3), homocysteine inducible ER protein with ubiquitin like domain 1 (HERPUD1), growth arrest and DNA damage inducible alpha (GADD45α) (Fig. 2e, Supplementary Fig. 5), as well as protein expression of binding immunoglobulin protein (BiP) and C/EBP homologous protein (CHOP) Fig. 2f, Supplementary Fig. 6)14,15. The gene discussed is HSPA5; the disease is neoplasm.