CALR and central nervous system cancer: We found that glioma cells treated with TMZ transiently increased the translocation of the chaperone protein calreticulin, a pro-phagocytosis molecule that interacts with low density lipoprotein receptor-related protein 1 (LRP1)/CD91 receptor on phagocytes, from the ER lumen to the plasma membrane in a dose-dependent manner (Fig. 2a, b).