Interestingly, the sequential arm, in which TMZ was given alone in advance followed by TMZ plus anti-CD47 antibody, resulted in significantly improved tumor growth inhibition and survival as compared to monotherapy and concurrent treatment arms in both GL261 and CT-2A models (Fig. 5a, b; Supplementary Fig. 13b, c; Supplementary Fig. 14). Here, CD47 is linked to neoplasm.