Although we cannot clarify the reason why the localizations are different in cell lines and human breast cancer samples, this differences are also observed in proteinatlas websites, which shows that RNF187 is mainly localized in the nuclear in cell lines (https://www.proteinatlas.org/ENSG00000168159-RNF187/cell#human), while in the cytosol in human samples (https://www.proteinatlas.org/ENSG00000168159-RNF187/pathology/breast+cancer#img). Here, RNF187 is linked to breast cancer.