Similarly, injections with Aβ peptide in the EC caused increased GFAP intensity and larger GFAP cell somas [23], streptozotocin-induced AD in rats resulted in increased numbers of GFAP+ cells in the EC [24], and numbers of GFAP+ cells were increased in the EC of APP/Tau transgenic mice [69]. Here, MAPT is linked to Alzheimer disease.