To investigate the direct effects of RUNX1 on BIRC5, NFKBIA and CSF2RB transcription and expression in NB cell lines, we used JASPAR (http://jaspar.genereg.net) to first identify the binding profile of the transcription factor RUNX1 [14, 15] in vertebrates (Fig. 5a). The gene discussed is CSF2RB; the disease is neuroblastoma.