RUNX1 and neuroblastoma: To determine how RUNX1 transcription factor regulates apoptosis, we first analyzed the publicly available datasets of 498 NB cases (GSE49710) and 649 NB cases (GSE45547) derived from the Gene Expression omnibus (GEO) which correlated with RUNX1 and the apoptosis gene of RUNX1 derived from the KEGG [13] datasets and ChIP-X (Fig. 4a).