BIRC5 and neuroblastoma: ChIP and qPCR assays indicated that overexpression of RUNX1 facilitated the binding of BIRC5, NFKBIA and CSF2RB promoter regions in NB cells; conversely, stable knockdown of RUNX1 decreased the binding of BIRC5, NFKBIA and CSF2RB promoter regions (Fig. 5b).