VWF and thrombocytopenic purpura: The condition is caused by the formation of unusually large von Willebrand factor (vWF) multimers (ULVWFMs) owing to the deficiency of vWF cleaving protease (VWF-CP) [1]; this causes abnormal platelet aggregation and results in thrombocytopenic purpura, hemolytic anemia, and microangiopathy in vital organs such as the brain and kidney [1, 2].