If ANXA2 acts as a chemoattractant and regulates the migration and adhesion of tumor cells and HO-1 halts tumor adhesion to the bone compartment, understanding how HO-1/ANXA2 axis impacts on PCa skeletal metastasis is critical to identify the signaling cascades that govern the skeletal complication of PCa progression. The gene discussed is ANXA2; the disease is posterior cortical atrophy.