IDO1 and Sepsis: Administration of DCs can efficiently arrest the induction of the immune suppression function of the residual DCs in septic mice, it diminished the proliferation and differentiation of Treg cells and suppressor T cells via a combination of factors like indoleamine 2,3 deoxygenase (IDO) and IL-10, enhanced the immune clearance of sepsis-causing pathogens, and eventually reduced organ damage, thereby improving the therapy effect [130,131].