In addition to the glycolytic enzymes ENO1 and TPI1, lactate dehydrogenase A (LDHA) was also identified in our study and corresponds to a central enzyme in regulating the Warburg effect; it catalyzes the conversion of lactate to pyruvate in the final stage of anaerobic glycolysis and is upregulated in various cancers [137,138]. Here, TPI1 is linked to cancer.