PKM and neoplasm: PDAC immunohistochemical images were analyzed, and six proteins (L-lactate dehydrogenase A chain, LDHA; Phosphoglycerate kinase 1, PGK1; Pyruvate kinase, PKM; 14-3-3 protein sigma, SFN; Fibronectin, FN1; Galectin-1, LGALS1) showed medium or high immunostaining in PDAC tumor tissue, while low or not detected in normal pancreatic tissue, indicating that these proteins are also potentially biopsy-based markers to screening PDAC patients with high-risk (Figure 9 and Figure S4).