Proteins with increased expression in cancers identified here, such as Galectin-3 (LGALS3), Peptidyl-prolyl cis-trans isomerase A (PPIA), Alpha-enolase (ENO1), L-lactate dehydrogenase A chain (LDHA), Protein/nucleic acid deglycase DJ-1 (PARK7), and Cathepsin D (CTSD), also confer resistance to chemotherapy [157,158,159,160,161,162,163,164,165]. The gene discussed is LGALS3; the disease is cancer.