Comparative analyses of the HCC wild type and PDK1-rich IR-resistant clones (HCC-R) revealed a 1.40-fold increase in the SP in Mahlavu-R compared to its wild type counterpart; similarly compared to Hep3B or Huh7 cells, the SP was increased by 2.14-fold or 7.03-fold in Hep3B-R or Huh7-R cells, respectively (Figure 3C). The gene discussed is PDK1; the disease is hepatocellular carcinoma.