PDK1 and breast carcinoma: Having said this, our finding is consistent with the recently demonstrated role of PDK1 as a crucial regulator of cancerous cell migration, invasion and dissemination, while concomitantly modulating the activation status of several oncogenic proteins, including PI3K and AKT/PKB [29], as well as evidence indicating that altered PDK1 expression is a crucial component of the oncogenic PI3K/AKT signaling in breast cancer, and that the targeting of PDK1 sensitizes cancerous cells to therapy [30].