Results of our differential expression profiling of the Wurmbach liver cohort (n = 75), with 45 context-relevant sample, revealed concomitant significant up-regulation of PI3K (1.22-fold, p = 0.030), PDK1 (2.17-fold, p = 8.95 × 10−6), mTOR (1.37-fold, p = 6.26 × 10−4) and statistically insignificant down-regulation of AKT mRNA (−1.14-fold, p = 0.847) in HCC samples (n = 35) compared to the normal liver tissues (n = 10; Figure 1A). This evidence concerns the gene MTOR and hepatocellular carcinoma.