As shown in Figure 6 we observed a three-fold increase of the M1/M2 ratio in mice injected with FL Rnaset2-overexpressing C51 cells in comparison to C51 P mice and a much more enhanced ratio in comparison to C51 E control mice, thus reinforcing the notion that Rnaset2 is able to influence the host macrophage compartment towards an increase of the intra-tumor M1/M2 macrophage ratio. Here, RNASET2 is linked to neoplasm.