Murine parental TS/A breast adenocarcinoma (TS/A P) and C51 colon carcinoma (C51 P) cells were first investigated by western blot analysis to assess their endogenous expression level of Rnaset2. As shown in Figure S1, both lines showed very low Rnaset2 expression at the protein level, thus making them suitable for gene overexpression-based analysis. Here, RNASET2 is linked to breast adenocarcinoma.