However, when the same xenograft-based assays were carried out in the less aggressive OVCAR3 cell line, the oncosuppressive role of human RNASET2 was clearly observed in both in vitro and in vivo experimental settings [2] suggesting that the amplitude of RNASET2-mediated tumor suppressive effects was somehow cell line-dependent, possibly based on the intrinsic tumorigenic potential of the chosen cellular model. Here, RNASET2 is linked to neoplasm.