Conversely, M1-like macrophage induction correlates with better control of tumor growth and also stimulation of anti-tumor protective adaptive T cells [39,40], in particular with CD4+ TH1 cells, which are key activators in the priming phase, and CD8+ T cytolytic cells in the rejection effector response against tumor [41,42,43,44]. Here, CD4 is linked to neoplasm.