CXCL8 and gingivitis: In conclusion, we determined for the here tested dihydrochalcone structure fragments, the most favorable combination is a trihydroxylated A-ring moiety with a vanilloylic B-ring moiety regarding a pgLPS-induced IL-8 release reducing effect in human gingival fibroblasts (HGF-1 cells), as a well-established model of gingivitis.