VEGFA and mitochondrial disease: Indeed, RE was reported to be able to maintain or enhance human cerebrovascular functions [14], modulate in vitro angiogenesis through the expression of vascular endothelial growth factor (VEGF) and the formation of new vascular networks [15], stimulate human immune cell functions [16], promote rat cell viability and proliferation [17], ameliorate mitochondrial respiratory dysfunction, and enhance cellular reprogramming in human fibroblasts derived from patients with a mitochondrial disease [18], a phenomenon potentially mediated by the activation of Sirtuins [19].