GHRL and obesity due to melanocortin 4 receptor deficiency: In addition, guggulsterone (Myrrha sterols) acts as an anti-obesity agent as it decreases adipogenesis through preventing the differentiation of preadipocytes into mature adipocytes [58] and decreases food intake and body weight gain in rats fed HFD due to it reduces the plasma ghrelin, glucose, triglyceride levels and increased plasma leptin, serotonin, dopamine levels [59].