The results of our study revealed that feeding rats HFD increased food intake, liver and body weights and induced hyperglycemia, dyslipidemia, hyperketonemia, hypoleptinemia, hypoadiponectinemia and oxidative stress in hepatic tissue accompanied with alteration of liver structure and function and decreased protein expression of UCP1 in brown adipose tissue. Here, UCP1 is linked to adiponectin deficiency.