The other possible reason behind the anti-obesity effect of CME in our study is its antioxidant activity as our results revealed that administration of rats fed HFD with CME alleviated HFD induced oxidative stress through decreasing lipid peroxidation and enhancing the antioxidant enzyme activity of hepatic tissues (Table 6) and it has been reported that administration of high fructose diet fed rats with Commiphora Mukul decreases MDA levels while increases GR activity that preserving GSH contents in hepatic tissues [19]. This evidence concerns the gene GSR and obesity due to melanocortin 4 receptor deficiency.