Metabolic reprogramming is regulated by HIF-1alpha and fostered by diverse oncogenic signaling pathways, including aberrant activation of the PI3K–AKT–mTOR pathway, activation of oncogenes (e.g., MYC, NFkappaB), or loss of tumor suppressors (e.g., phosphatase and tensin homolog, PTEN, TP53, CDKN2A), recurrently observed in malignant lymphomas [83]. The gene discussed is PIK3CD; the disease is lymphoma.