SELP and deep vein thrombosis: Depletion of mast cells in an experimental mouse model confers protection from DVT, as the immune system activation is impaired: mast cell histamine fails to trigger endothelial cell release of Wiebel–Palade bodies containing von Willebrand’s factor and the adhesion proteins P-selectin and ICAM-1, which are implicated in monocyte recruitment [141].