Further, the deletion of claudin-12 resulted in a greater reduction in permeability to calcium than to sodium (PCa/PNa = 1.51 ± 0.08, Figure 5A), which was also reflected in decreased absolute calcium permeability (7.1 ± 0.8 × 10−4 cm/s in the WT compared with 3.8 ± 0.5 × 10−4 cm/s in the KO) (Figure 5B, PCa). The gene discussed is CLDN12; the disease is posterior cortical atrophy.