On the contrary, SAMHD1 enhances the activity of drugs used to treat solid tumors, such as floxuridine, most often used in the treatment of colorectal cancer, fluorouracil, used for colon cancer, esophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer, and anti-folate drugs, such as methotrexate, used against a number of cancers but also to treat autoimmune diseases, such as psoriasis, rheumatoid arthritis, and Crohn’s disease, or pemetrexed, used to treat non-small cell lung cancer [36]. This evidence concerns the gene SAMHD1 and esophageal cancer.