Interestingly, GRIN1 mutation seizure phenotypes exhibit variable semiology (spasms, tonic and atonic seizures, hypermotor seizures, focal dyscognitive seizures, febrile seizures, generalized seizures, status epilepticus, myoclonic seizures, etc.)and electroencephalogram (EEG) patterns (hypsarrhythmia, focal, multifocal and generalized spikes and waves), and appear to be independent of channel function (both loss-of-function or gain-of-function GRIN1 mutation phenotypes exhibit seizures) [74,75]. This evidence concerns the gene GRIN1 and status epilepticus.