Reversibly disulfide-crosslinked pullulan nanoparticles with folic acid decoration were fabricated for dual-targeted and reduction-responsive anti-tumor drug delivery due to the specific affinity of pullulan and folic acid to overexpressed ASGPR (asialoglycoprotein receptor) and FR (folate receptor) on the surface of tumor cells, respectively [57]. This evidence concerns the gene ASGR1 and neoplasm.