FH and renal cell carcinoma: FH is a tricarboxylic acid (TCA) cycle enzyme and thus FH-RCC tumors are characterized by impairment of the TCA cycle and of oxidative phosphorylation with a resultant metabolic shift to aerobic glycolysis which can be therapeutically targeted by the combination of erlotinib (inhibitor of cell membrane glucose transporters) with bevacizumab (inhibitor of glucose delivery via tumor neovasculature) [36].