Based on our topology analysis, hubba nodes screened, and protein–protein interaction network constructions of terpenes, two bottleneck node proteins, APP [57] and ESR1 [58], and two AD-associated targets, ACHE [59] and NOS2 [60], were chosen as the basis for the compound-ligand interaction analysis by AutoDock for preliminary studies aimed at investigating the anti-AD effects of terpenes. Here, ESR1 is linked to Alzheimer disease.