As outlined earlier, we have previously shown higher NR3C1 methylation levels in the children of mothers with the incongruent low prenatal and high postnatal depression than congruent high prenatal–high postnatal levels, and mediation by NR3C1 methylation of the association with later anxious‐depressed symptoms, in girls only (Hill, Pickles, Wright, Quinn, et al., 2019; Hill, Pickles, Wright, Braithwaite, et al., 2019; Murgatroyd et al, 2015). The gene discussed is NR3C1; the disease is postpartum depression.