In addition, tumors shedding EGFR mutant ctDNA in plasma had significantly larger tumor diameter (median [range], 5.45 [4.9–6.0] cm vs. 2.5 [0.8–3.5] cm; p = 0.027), tumor volume (median [range], 64.0 [44.60~83.40] cm3 vs. 5.45 [0.48–21.80] cm3; p = 0.027), and higher mitotic rate (median [range] per 10 HPFs, 16 [14–18] vs 0 [0–5]; p = 0.009) than non-shedding tumors (Table 6). This evidence concerns the gene EGFR and neoplasm.