It has also been reported that Bacteroides, Parabacteroides and Alistipes are strongly associated with tumor growth, whereas several members of Clostridium cluster including XIVa are associated with reduction in CRC tumor.[44] In the current investigation, we also found a similar trend in that ETO-Cur-TRF induced inhibition of tumor growth was associated with a greater abundance of Clostridium XIVa. This evidence concerns the gene RUNX1T1 and neoplasm.