In contrast, M2 macrophages promote tissue repair and angiogenesis, and favor tumor progression by producing anti-inflammatory cytokines such as interleukin (IL)-4, IL-10, IL-13 and tumor growth factor (TGF)-β, and high level expression of arginase-1, and can be identified by the expression of CD36, CD163, CD206 and CD301 on their cell surface [22, 23]. This evidence concerns the gene TGFB1 and neoplasm.