Immunoblot analysis indicated that steady-state levels of STAT1 and STAT2 were not affected by infection, while phosphorylation of STAT1 at Tyr701 and STAT2 at Tyr690 (p-STAT1 or p-STAT2) was greatly reduced in TBEV infection compared with VSV-infected cells (Figure 3(A)). The gene discussed is STAT1; the disease is infection.