ESR1 and Lymphadenopathy: In the univariate analysis, age (HR, 4.850 [95% CI [1.805‐15.24]], P = .0015), Ann Arbor stage III‐IV (HR, 10.33 [95% CI (2.876‐65.90]], P < .0001), number of lymphadenopathy areas (HR, 5.981 [95% CI [2.153‐19.14]], P = .0006), high‐risk FLIPI (HR, 9.157 [95% CI [3.156‐33.00]], P < .0001), follicular pattern (another pattern, including the diffuse pattern, at baseline) (HR, 0.328 [95% CI [0.127‐0.848)], P = .0222), and ERα/HPF (HR, 0.232 [95% CI [0.037‐0.825]], P = .0213) were significantly associated with PFS.