Surprisingly, while we did determine that NNT contributes to the NADPH:NADP+ ratio in NSCLC cells, the accompanying increase in mitochondrial ROS was not sufficient to compromise the mitochondrial protein antioxidant system, nor sensitize NNT-deficient cells to treatment with oxidants (Figs. 2 and S1). The gene discussed is NNT; the disease is non-small cell lung carcinoma.