Thyroid transcription factor-1 reportedly regulates SFTPC transcription directly or by connecting the transcriptional co-activator with the PDZ-binding motif.[14] In fact, the combination of 2 mutations can damage pulmonary SP homeostasis and gas exchange, lower oxyhemoglobin saturation, and cause recurrent pulmonary infection and rapid progression of lung disease. This evidence concerns the gene SFTPC and lung disorder.