In addition, the inflammatory markers TNF-α, IL-1β, IL-6, and IL-8 and IL-10 will be determined by 8-plex high sensitivity human cytokine per Millipore (Millipore Corporation, Billerica, MA), where Marques Filho et al[43] found high levels of these cytokines in the crevicular fluid of patients with peri-implantitis. Here, CXCL8 is linked to Peri-Implantitis.