However, examination of gene expression of additional ApoE receptor family,[36,38] such as LRP1, LRP2 (megalin), LRP4, LRP5/LRP6, apoER2/LRP8, LRP1B, and SORL1, showed that they were all down-regulated in GBM compared with LGG (Fig. 3). This evidence concerns the gene LRP6 and glioblastoma.