Upon comparing the expression of LINC00263 in these three periods, it was found that the expression of LINC00263 in PE was the highest, followed by MSE, indicating that the expression of LINC00263 in the endometrium increased with the increase in estrogen level during the normal menstrual cycle (Fig. 6i).33 Similarly, compared to the control group, after treatment with E2, the expression of LINC00263 was increased in postmenopausal women (Fig. 6j) in the vaginal epithelium,34 indicating that LINC00263 is inversely affected by estrogen in breast cancer and the normal endometrium or vagina. This evidence concerns the gene OLMALINC and breast cancer.