Patients with cardiovascular disease display a significantly higher mtDNA methylation of genes encoding for cytochrome c oxidases (MT-CO1, MT-CO2, MT-CO3), tRNA leucine 1 (MT-TL1) and (1.67%, P = 0.0001) as well as genes involved in ATP synthesis (MT-ATP6 and MT-ATP8) (113). Here, MCAT is linked to cardiovascular disorder.