Meng et al. (2019) demonstrated that PPAR-γ activation exerts an anti-inflammatory effect by suppressing NLRP3 inflammasome activation in spinal cord-derived neurons. Further, NLRP3 inflammasome activation has been reported in microglia and neurons after OGD/reperfusion in vitro and during cerebral ischemia/reperfusion (Gong et al., 2018; Guo et al., 2018). Here, PPARG is linked to brain ischemia.