BECN1 and cardiomyopathy: However, the role of YY2-induced autophagy in the pathogenesis of cardiomyopathy remains unclear; the haplo-insufficiency of Beclin1 (Beclin 1±), which is protective against cardiac remodeling in response to pressure overload in mice (Zhu et al., 2007), failed to ameliorate YY2-induced cardiac phenotypes (data not shown).