COL1A1 and metabolic dysfunction-associated steatohepatitis: Consistent with these findings, we noted that the mRNA expression of profibrogenic markers, including collagen 1α1 (Col1α1), connective tissue growth factor (CTGF), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1), were markedly increased in NASH livers than that in NCD-fed livers; however, myricetin administration remarkably abrogated the effect of CDAHFD and downregulated the expression of these profibrogenic markers (Figure 3F).