Additionally, STAT3 and JNK signaling are progressively elevated in livers of NASH (7, 46), in this study, we found that p-STAT3 and p-JNK were also increased in LPS-stimulated RAW264.7 cells, however, myricetin pre-treated to LPS-stimulated RAW264.7 cells led to lower the increased expression of the p-STAT3 and p-JNK as compared with vehicle-treated to the cells (Figures 8A,C,D). Here, MAPK8 is linked to metabolic dysfunction-associated steatohepatitis.