CD163 and metabolic dysfunction-associated steatohepatitis: We applied chitinase-3-like 3 and 4 (also known as Ym-1 and Ym-2 in mice, respectively) and CD163 as molecular markers of M2-polarized macrophage (5, 45); and we noted that M2 macrophages in the liver were slightly increase in NASH mice induced by CDAHFD for 8 weeks as assessed by the Ym-1/Ym-2 and CD163 immunostaining (Figures 5A,B); however, NASH mice with myricetin treatment enhanced the density of Ym-1/Ym-2 and CD163 staining when compared with the NASH mice with vehicle treatment (Figures 5A,B).