As a further corroboration, the M2 skewing was supported by the quantitative RT-PCR for selective M2-polarized markers such as CD163, IL-10, and Ym-1; and our results demonstrated that myricetin increased expression of CD163 and IL-10 mRNA, but there was no difference in Ym-1 gene expression between the myricetin-treated NASH mice and vehicle-treated NASH mice (Figure 5E). The gene discussed is IL10; the disease is metabolic dysfunction-associated steatohepatitis.