The univariate and multivariate cox regression of overall survival were applied in METABRIC database and immune score was confirmed to be a protector (HR = 0.88, 95% CI: 0.77–0.99, p = 0.039) with younger age (HR = 0.45, 95% CI: 0.35–0.57, p = 0.039), ER-positive (HR = 0.85, 95% CI: 0.71–1.02, p = 0.08), HER2-negative (HR = 0.69, 95% CI: 0.58–0.84, p < 0.001), smaller tumor size (HR = 0.66, 95% CI: 0.58–0.75, p < 0.001) and no metastasis lymph nodes (HR = 0.63, 95% CI: 0.53–0.75, p < 0.001) as demonstrated in Figure 7B. Here, ERBB2 is linked to neoplasm.