The haploinsufficient tumor suppressor and critical autophagy effector protein Beclin 1 (the mammalian ortholog of yeast Atg6) is also a key member of the PI3K complex, and can regulate autophagy through its ability to interact with members of the anti-apoptotic BCL-2 family (Yue et al., 2003; Pattingre et al., 2005). The gene discussed is BECN1; the disease is neoplasm.