DAPK1 and Alzheimer disease: Pin1 ablation or inhibition induces the development of AD pathologies (Liou et al., 2003; Pastorino et al., 2006; Lu and Zhou, 2007; Lim et al., 2008), suggesting that aberrant DAPK1 activation might contribute to the age-dependent neurodegeneration in AD by inhibiting Pin1 function.