In this regard, and given the role of Wnt5a in the turnover of focal adhesions in GC cells, it will be of interest to analyze the composition of IACs in GC cells cultured on substrates with elasticities like those found in vivo in gastric cancer, and to confirm if Wnt5a does modulate IAC turnover in these mechanical contexts. The gene discussed is WNT5A; the disease is gastric cancer.