WNT5A and neoplasm: In this regard, a better understanding of the mechanisms of Wnt5a signaling in GC might allow the development of drugs targeting specific biological interactions triggered by this ligand, and which might also be employed in other cancers where the non-canonical pathway plays a relevant role in tumor progression and metastasis (Kikuchi et al., 2012; Endo et al., 2015; Asem et al., 2016).