Since the discovery of FLCN as the causative gene for BHD syndrome, subsequent work has established that FLCN protein can form complexes with FNIP1 (Baba et al., 2006) and FNIP2 (Hasumi et al., 2008; Takagi et al., 2008), with the same behavior confirmed for their respective orthologs in yeast, Lst7 and Lst4 (Pacitto et al., 2015). The gene discussed is FLCN; the disease is Birt-Hogg-Dubé syndrome.