SPHK1 and malaria: Toward this, we report for the first time that host-mediated SphK-1 level and its phosphorylation status decrease during malaria infection (Figures 1A, 2A) that could be the possible reasons underlying the reduced levels of S1P in the sera of malaria-infected patients, in line with the previous studies (Pitson, 2011; Punsawad and Viriyavejakul, 2017).