TBX2 and melanoma: In this realm, the transcription factor TBX2 overexpression has been directly linked to several cancers, including rhabdomyosarcoma (Zhu et al., 2016), breast (Jacobs et al., 2000; Redmond et al., 2010), melanoma (Vance et al., 2005; Peres et al., 2010), nasopharyngeal (Lv et al., 2017), and prostate cancers (Du et al., 2017).