Furthermore, the KEYNOTE-181 trial revealed that in all PD-L1 positive patients, ESCC ones might have better ORR (22.0 vs. 18.0%), mPFS (3.2 vs. 2.1 months), and mOS (10.3 vs. 6.3 months) than EAC ones (47). Here, CD274 is linked to esophageal squamous cell carcinoma.