Among these, muscle RING finger-containing protein 1 (MURF1, also known as TRIM63) and muscle atrophy F box protein (MAFbx, also known as Atrogin-1) are defined as muscle-specific E3 ubiquitin ligases and are the most widely studied in the case of cachexia-associated muscle loss. This evidence concerns the gene FBXO32 and Cachexia.