Further examples of potentially useful GEM for research on CC are the KL model (KRASG12D/+; LKB1f/f), recently used to study the metabolic profile of advanced non-small cell lung cancer (NSCLC) (152), and the lately developed KPC:APC model (APCf/f; KRAS+/f; CDX2-Cre-ERT2), which aims to recapitulate features of human colorectal carcinoma (CRC) with mutated KRAS and leads to development of CC (153). Here, MAPK3 is linked to cholangiocarcinoma.