PGP and cancer: Among these, substrates for P-gp included anti-cancer small molecules such gedatolisib (PKI-587, phosphoinositide 3-kinase/mammalian target of rampamycin inhibitor), AT7159 (cyclin-dependent kinase inhibitor), AT9283 (Janus kinase 2/3 inhibitor), and ispinesib (kinesin spindle protein inhibitor) (65).