Niu et al. found miR-181a decreased the apoptosis of triple-negative breast cancer cells upon doxorubicin treatment through suppression of the pro-apoptotic protein BAX directly (81), while another report showed miR-181a enhanced adriamycin-induced apoptosis by targeting the anti-apoptotic protein Bcl-2 in low-invasive breast cancer cells (82). This evidence concerns the gene BAX and breast carcinoma.