Overexpression of miR-186 sensitized A2780/Taxol cells to taxol by targeting ABCB1 (57), as well as sensitized NSCLC cells A549 and H1299 to paclitaxel in vitro and in A549 xenografts by targeting MAPT (microtubule associated protein tau), which promoted microtubule assembly and leads to microtubule stabilization, by binding to the surfaces of microtubules outside and inside, interfering with the action of taxanes since they also bind to the inside surfaces (58). This evidence concerns the gene MAPT and non-small cell lung carcinoma.