Results from another study carried out on rat glioma cell line (C6) and doxorubicin (anti-cancer agent) highlighted the significance of nuclear pore complex in cancer therapy and proposed that the mechanism of nuclear export and the maintenance genes of CSCs could be suppressed by inhibitors at appropriate phase while keeping the tumor-suppressing capacities of PER2 expression (144). This evidence concerns the gene PER2 and central nervous system cancer.