IL6 and neoplasm: We also observed that IL6 could promote cell proliferation of liver cancer cells H22 and Hepa1-6 in vitro, and the IL6 neutralized antibody could block the enhancement of cell proliferation and tumor sphere formation of Hepa1-6 induced by MDSC-secreted cytokines (Figures 6F,G and Supplementary Figures 4C–E).