Moreover, intravenous injection of rhBMP2 and implantation of rhBMP2 collagen gels in tumor-burdened mice could increase the IL6 levels in both peripheral blood and tumor tissues (Figures 6D,E and Supplementary Figures 4A,B), indicating that MDSC expansion, induced by BMP2, enhanced liver cancer growth via IL6. This evidence concerns the gene IL6 and neoplasm.