In contrast, when the expression of FAM83A was downregulated with SiRNA interference in H1299 (H1299-SiFAM83A) and A549 (A549-SiFAM83A) cells, the proliferation rate (H1299-SiFAM83A, P < 0.001; A549-SiFAM83A, P < 0.001) and number of colony formations (H1299-SiFAM83A, P = 0.0091; A549-SiFAM83A, P < 0.001) of lung cancer cells were significantly decreased compared with those of control cells (Figures 2C,F,G). This evidence concerns the gene SACK1A and lung carcinoma.